Suppression of blood glucose level elevation and promotion of GLP-1 secretion by ingestion of Undaria pinnatifida sporophylls (Mekabu): Open-label crossover design

Background: It has been confirmed that the daily consumption of seaweed such as Wakame (Undaria pinnatifida) and Kombu (Saccharina japonica) an inhibitory effect on rise in postprandial blood glucose levels. Similar effects can also be expected for Mekabu, which is sporophylls contains large quantities water-soluble dietary fiber. In this study, we examined preprandial intake Mekabu levels regulation-related hormones healthy young women.Methods: The subjects were ten adult women. was eaten, followed by rice only. Blood sampled five times: while fasting (0 min), 15, 30, 90, 120 minutes after eating. Measurements taken level hormones.Result: Eating before resulted a significant reduction Δglucose Δinsulin at 30 ingestion (p = 0.034, p 0.049, respectively). concentration glucagon-like peptide-1 (GLP-1) plasma higher eating 0.044), 60 0.0.31), 0.019) when eaten preprandially.Conclusions: present GLP-1 secretion sustained sporophylls, rice. Our results suggest ingesting amounts viscous alginic acid, prior to meal not only suppresses level, but supports extended GLP-1, providing sustainable incretin effect.